Enhanced cytotoxicity and apoptosis by thymoquinone in combination with zoledronic acid in hormone- and drug-resistant prostate cancer cell lines

Dirican A., Erten C., ATMACA H., Bozkurt E., KÜÇÜKZEYBEK Y., Varol U., ...Daha Fazla

JOURNAL OF BUON, cilt.19, sa.4, ss.1055-1061, 2014 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2014
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1055-1061
  • Anahtar Kelimeler: apoptosis, prostate neoplasm, thymoquinone, zoledronic acid, BISPHOSPHONATES, CISPLATIN, SURVIVAL, GROWTH
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Thymoquinone (TQ), an active ingredient of black seed oil (Nigella Sativa), has been shown to possess cytotoxic activity against a variety of cancer cell lines. Our purpose was to investigate if the cytotoxic and apoptotic effect of zoledronic acid (ZA) can be enhanced by the addition of the TQ in hormone- and drug-refractory prostate cancer cells PC-3 and DU-145.