Purpose: The aim of this study was to evaluate the efficacy of complex decongestive physiotherapy (CDP) in patients with upper extremity lymphedema. Materials and methods: One hundred-two women with lymphedema after having breast surgery and adjuvant radiotherapy were included in this study. The subjects were divided into three groups as mild lymphedema (N=31), moderate lymphedema (N=34), and severe lymphedema (N=37). They were treated with CDP applications of daily manual lymph drainage, compression bandage, remedial exercises and skin care, for five days per week, four weeks. They also received a prophylactic physiotherapy and education for self-management techniques. Lymphedema was assessed through circumference and volumetric measurements before and after the treatment. Results: Volume of lymphedema was found to be decreased significantly in each group after CDP (p<0.05). A statistically significant difference was found when volume changes among the groups were compared before and after the treatment (p<0.05). The mean reduction in the volume of edematous arm was 87% in the women with mild lymphedema, 56% with moderate lymphedema, and 30% with severe lymphedema. Conclusion: The CDP, combined with self management, is efficacious in treating patients with upper extremity lymphedema, and it was detected that the earlier the subjects receive physiotherapy, the faster they recover.