Relation of asymmetric dimethylarginine and cardiac involvement in systemic sclerosis

Dag S., Budulgan M., DİLEK B., Batmaz I., Ariturk Z., Nas K., ...More

ACTA REUMATOLOGICA PORTUGUESA, vol.39, no.3, pp.228-235, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2014
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.228-235
  • Keywords: Systemic sclerosis, Pulmonary hypertension, Asymmetric dimethylarginine, SCLERODERMA, DISEASE, HEART
  • Dokuz Eylül University Affiliated: Yes


Objectives: The heart is a commonly involved organ in systemic sclerosis (SSc) and pulmonary hypertension is a commonly observed complication that is associated with poor prognosis in this disease. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases. In this study, we aimed to contribute to an early diagnosis of cardiac involvement by evaluating ADMA and tissue Doppler echocardiographic findings in patients with SSc.