New prospects for management and treatment of inoperable and recurrent skull base meningiomas

Johnson M. D., SADE B., Milano M. T., Lee J. H., Toms S. A.

JOURNAL OF NEURO-ONCOLOGY, cilt.86, sa.1, ss.109-122, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 86 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s11060-007-9434-z
  • Dergi Adı: JOURNAL OF NEURO-ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.109-122
  • Anahtar Kelimeler: meningiomas, skull base, chemotherapy, MAPK, Akt, COX-2 inhibitors, PLC-gamma, GROWTH-FACTOR RECEPTOR, GAMMA-KNIFE RADIOSURGERY, FRACTIONATED STEREOTACTIC RADIOTHERAPY, INTENSITY-MODULATED RADIOTHERAPY, CAVERNOUS SINUS MENINGIOMAS, LONG-TERM EXPERIENCE, FARNESYL TRANSFERASE INHIBITORS, ACTIVATED PROTEIN-KINASE, ALPHA TGF-ALPHA, PETROCLIVAL MENINGIOMAS
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Skull base, including optic nerve, cavernous sinus, clival and foramen magnum tumors represent a major challenge for neurosurgeons and neuro-oncologists. Growth regulatory signaling pathways for these tumors are of increasing interest as potential targets for new chemotherapy. Those differentially activated in various grades of meningiomas are currently being identified as well. This article reviews some recent findings pathways that appear to regulate meningioma growth. Potential targets for novel therapies are also discussed.