Associations between common 3435 C > T variants of the multi-drug resistance [MDR-1 (ABCB1)] gene and abdominal aortic aneurysm: a pilot study

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MANDUZ Ş., KATRANCIOĞLU N., Karahan O., YILMAZ M. B., ÖZDEMİR Ö., BERKAN Ö.

TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, vol.19, no.2, pp.177-181, 2011 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 19 Issue: 2
• Publication Date: 2011
• Doi Number: 10.5606/tgkdc.dergisi.2011.008
• Journal Name: TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.177-181
• Keywords: Abdominal aortic aneurysm, inflammation, MDR-1, gene polymorphism, reverse hybridization, P-GLYCOPROTEIN, EXPRESSION, CELLS, INFLAMMATION, DISEASE
• Dokuz Eylül University Affiliated: No

Abstract

Background: The aim of the study was to reveal the effect of the C3435T MDR-1 gene polymorphism in AAA, which has been postulated to play a role in the inflammatory process and protection against oxidative stress.