Erythropoietin attenuates neuronal injury and potentiates the expression of pCREB in anterior horn after transient spinal cord ischemia in rats

Sonmez A., Kabakci B., Vardar E., Gurel D., Sonmez Ü., Orhan Y. T., ...More

SURGICAL NEUROLOGY, vol.68, no.3, pp.297-303, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.surneu.2006.11.045
  • Journal Name: SURGICAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.297-303
  • Keywords: aorta, spinal cord ischemia, erythropoietin, pCREB, neuroprotection, rat, ELEMENT-BINDING PROTEIN, CEREBRAL-ISCHEMIA, HIPPOCAMPAL-NEURONS, CORTICAL-NEURONS, IN-VITRO, PHOSPHORYLATION, CREB, BRAIN, PREVENTION, KINASE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Recent studies have suggested that EPO activates the CREB transcription pathway and increases BDNF expression and production, which contributes to EPO-mediated neuroprotection. We investigated whether EPO has a neuroprotective effect against ISCI in rats and examined the involvement of CREB protein phosphorylation in this process.