Erythropoietin attenuates neuronal injury and potentiates the expression of pCREB in anterior horn after transient spinal cord ischemia in rats

Sonmez A., Kabakci B., Vardar E., Gurel D., Sonmez Ü., Orhan Y. T., ...Daha Fazla

SURGICAL NEUROLOGY, cilt.68, sa.3, ss.297-303, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.surneu.2006.11.045
  • Dergi Adı: SURGICAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.297-303
  • Anahtar Kelimeler: aorta, spinal cord ischemia, erythropoietin, pCREB, neuroprotection, rat, ELEMENT-BINDING PROTEIN, CEREBRAL-ISCHEMIA, HIPPOCAMPAL-NEURONS, CORTICAL-NEURONS, IN-VITRO, PHOSPHORYLATION, CREB, BRAIN, PREVENTION, KINASE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Recent studies have suggested that EPO activates the CREB transcription pathway and increases BDNF expression and production, which contributes to EPO-mediated neuroprotection. We investigated whether EPO has a neuroprotective effect against ISCI in rats and examined the involvement of CREB protein phosphorylation in this process.