Erythropoietin attenuates neuronal injury and potentiates the expression of pCREB in anterior horn after transient spinal cord ischemia in rats

Sonmez, ATAÇ; Kabakci, Birol; Vardar, Enver; Gurel, DUYGU; Sonmez, ÜLKER; Orhan, Yahya; Acikel, Uenal; Gokmen, ALİ

doi:10.1016/j.surneu.2006.11.045

Erythropoietin attenuates neuronal injury and potentiates the expression of pCREB in anterior horn after transient spinal cord ischemia in rats

Sonmez A., Kabakci B., Vardar E., Gurel D., Sonmez Ü., Orhan Y. T., ...Daha Fazla

SURGICAL NEUROLOGY, cilt.68, sa.3, ss.297-303, 2007 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 68 Sayı: 3
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.surneu.2006.11.045
Dergi Adı: SURGICAL NEUROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
Sayfa Sayıları: ss.297-303
Anahtar Kelimeler: aorta, spinal cord ischemia, erythropoietin, pCREB, neuroprotection, rat
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Recent studies have suggested that EPO activates the CREB transcription pathway and increases BDNF expression and production, which contributes to EPO-mediated neuroprotection. We investigated whether EPO has a neuroprotective effect against ISCI in rats and examined the involvement of CREB protein phosphorylation in this process.