EUROPEAN JOURNAL OF ANAESTHESIOLOGY, vol.20, no.9, pp.690-696, 2003 (SCI-Expanded)
Background and objective: An inverse I:E ratio (inspiratory time > expiratory time) may have benefits in patients suffering trauma who requiring lung ventilation. However, this application may be deleterious if there is concomitant head injury. We aimed to determine the physiological effects of pressure- and volume-controlled modes of inverse ratio (I:E = 2:1) ventilation of the lungs, while maintaining normocapnia, in a rabbit model of raised intracranial pressure (ICP).