Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)(2)(NH3)(2)] and cis-[Pt(tsac)(2)(NH3)(2)]

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Al-Jibori S. A., Al-Jibori G. H., Al-Hayaly L. J., Wagner C., Schmidt H., TİMUR S., ...More

JOURNAL OF INORGANIC BIOCHEMISTRY, vol.141, pp.55-57, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 141
  • Publication Date: 2014
  • Doi Number: 10.1016/j.jinorgbio.2014.07.017
  • Journal Name: JOURNAL OF INORGANIC BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.55-57
  • Keywords: Cisplatin, Ammine, Saccharinate, Thiosaccharinate, X-ray structure, Anti-cancer, PLATINUM(II) COMPLEXES, CRYSTAL-STRUCTURES, MOLECULAR-STRUCTURE, METAL-COMPLEXES, CROSS-LINKING, CISPLATIN, DNA, PALLADIUM(II), CIS, CIS-DIAMMINEDICHLOROPLATINUM(II)
  • Dokuz Eylül University Affiliated: Yes

Abstract

The new platinum(II) complexes cis-[Pt(sac)(2)(NH3)(2)] (sac = saccharinate) and cis-[Pt(tsac)(2)(NH3)(2)] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)(2)(NH3)(2)]center dot H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. (C) 2014 Elsevier Inc. All rights reserved.