Atıf İçin Kopyala
Al-Jibori S. A., Al-Jibori G. H., Al-Hayaly L. J., Wagner C., Schmidt H., TİMUR S., ...Daha Fazla
JOURNAL OF INORGANIC BIOCHEMISTRY, cilt.141, ss.55-57, 2014 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
141
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Basım Tarihi:
2014
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Doi Numarası:
10.1016/j.jinorgbio.2014.07.017
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Dergi Adı:
JOURNAL OF INORGANIC BIOCHEMISTRY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.55-57
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Anahtar Kelimeler:
Cisplatin, Ammine, Saccharinate, Thiosaccharinate, X-ray structure, Anti-cancer, PLATINUM(II) COMPLEXES, CRYSTAL-STRUCTURES, MOLECULAR-STRUCTURE, METAL-COMPLEXES, CROSS-LINKING, CISPLATIN, DNA, PALLADIUM(II), CIS, CIS-DIAMMINEDICHLOROPLATINUM(II)
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Dokuz Eylül Üniversitesi Adresli:
Evet
Özet
The new platinum(II) complexes cis-[Pt(sac)(2)(NH3)(2)] (sac = saccharinate) and cis-[Pt(tsac)(2)(NH3)(2)] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)(2)(NH3)(2)]center dot H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. (C) 2014 Elsevier Inc. All rights reserved.