Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)(2)(NH3)(2)] and cis-[Pt(tsac)(2)(NH3)(2)]
JOURNAL OF INORGANIC BIOCHEMISTRY, vol.141, pp.55-57, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 141
- Publication Date: 2014
- Doi Number: 10.1016/j.jinorgbio.2014.07.017
- Journal Name: JOURNAL OF INORGANIC BIOCHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.55-57
- Keywords: Cisplatin, Ammine, Saccharinate, Thiosaccharinate, X-ray structure, Anti-cancer
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
The new platinum(II) complexes cis-[Pt(sac)(2)(NH3)(2)] (sac = saccharinate) and cis-[Pt(tsac)(2)(NH3)(2)] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)(2)(NH3)(2)]center dot H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. (C) 2014 Elsevier Inc. All rights reserved.