Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)(2)(NH3)(2)] and cis-[Pt(tsac)(2)(NH3)(2)]

Al-Jibori, Subhi; Al-Jibori, Ghassan; Al-Hayaly, Lamaan; Wagner, Christoph; Schmidt, Harry; TİMUR, SUNA; BARLAS, Fırat; SUBAŞI, ELİF; Ghosh, Shishir; Hogarth, Graeme

doi:10.1016/j.jinorgbio.2014.07.017

Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)(2)(NH3)(2)] and cis-[Pt(tsac)(2)(NH3)(2)]

Al-Jibori S. A., Al-Jibori G. H., Al-Hayaly L. J., Wagner C., Schmidt H., TİMUR S., ...Daha Fazla

JOURNAL OF INORGANIC BIOCHEMISTRY, cilt.141, ss.55-57, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 141
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.jinorgbio.2014.07.017
Dergi Adı: JOURNAL OF INORGANIC BIOCHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.55-57
Anahtar Kelimeler: Cisplatin, Ammine, Saccharinate, Thiosaccharinate, X-ray structure, Anti-cancer
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The new platinum(II) complexes cis-[Pt(sac)(2)(NH3)(2)] (sac = saccharinate) and cis-[Pt(tsac)(2)(NH3)(2)] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)(2)(NH3)(2)]center dot H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. (C) 2014 Elsevier Inc. All rights reserved.