The Ability to Generate Senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity

Mumcuoglu, Mine; Bagislar, Sevgi; Yuzugullu, Haluk; Alotaibi, HANİ; Şentürk, ŞERİF; Telkoparan, Pelin; Gur-Dedeoglu, Bala; Cingoz, Burcu; Bozkurt, Betul; Tazebay, Uygar; Yulug, Isik; Akcali, K.; Ozturk, Mehmet

doi:10.1371/journal.pone.0011288

The Ability to Generate Senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity

Mumcuoglu M., Bagislar S., Yuzugullu H., Alotaibi H., Şentürk Ş., Telkoparan P., ...Daha Fazla

PLOS ONE, cilt.5, sa.6, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 5 Sayı: 6
Basım Tarihi: 2010
Doi Numarası: 10.1371/journal.pone.0011288
Dergi Adı: PLOS ONE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background: Breast cancer is a remarkably heterogeneous disease. Luminal, basal-like, "normal-like", and ERBB2+ subgroups were identified and were shown to have different prognoses. The mechanisms underlying this heterogeneity are poorly understood. In our study, we explored the role of cellular differentiation and senescence as a potential cause of heterogeneity.