Cortical sulci and bipolar disorder

Coyle T. R., Kochunov P., Patel R. D., Nery F. G., Lancaster J. L., Mangin J., ...More

NEUROREPORT, vol.17, no.16, pp.1739-1742, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 16
  • Publication Date: 2006
  • Doi Number: 10.1097/01.wnr.0000239957.53072.f0
  • Journal Name: NEUROREPORT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1739-1742
  • Keywords: bipolar disorder, brain, cortical sulci, diagnostic imaging, magnetic resonance imaging, sulcal width, MOOD DISORDERS, BRAIN, SCHIZOPHRENIA, MORPHOMETRY, VOLUMES, CORTEX, MATTER
  • Dokuz Eylül University Affiliated: No


The width of cortical sulci in bipolar patients (n = 19) and healthy controls (n = 35) was examined using a novel automated technique involving magnetic resonance imaging. All sulci were wider for bipolar patients than for healthy controls. Bipolar-control differences were largest for the superior and intermediate frontal sulci, smallest for the occipital and cingulate sulci, and intermediate in magnitude for the other sulci (intraparietal, inferior frontal, and central sulci). The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci.