Bioevaluation of Tc-99m(CO)(3)-Guanine in vitro and in vivo

İÇHEDEF Ç., TEKSÖZ S., ÜNAK P., Senocak K., MEDİNE E. İ., ERTAY T., ...Daha Fazla

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.292, sa.2, ss.739-743, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 292 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10967-011-1493-0
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.739-743
  • Anahtar Kelimeler: Guanine, (99m)Technetium, Cell culture, Imaging
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study is to examine biological behaviour of radiolabeled guanine with [Tc(CO)(3)](+) core in vitro and in vivo. In vitro biological behavior of Tc-99m(CO)(3)-Gua was evaluated on Lung (A-549), Breast (MCF-7), Colonic (Caco) carcinoma cell lines and normal human bronchial epithelial (NHBE). Tc-99m(CO)(3)-Gua compound showed high uptake on A-549 cell line when compared to NHBE cell line. Biodistribution characteristics of Tc-99m(CO)(3)-Gua was evaluated using New Zeland Rabbits. Scintigraphic results showed that a high level of radioactivity was observed in the lungs and liver shortly after administration of the Tc-99m(CO)(3)-Gua and excretion takes place via both renal and hepatobiliary route. It was concluded that Tc-99m(CO)(3)-Gua could be used as a nucleotide radiopharmaceutical for imaging purposes.