The Relationship Between Prognosis and Plasma Cell Percentage; Infiltration Pattern, Fibrosis and Microvascular Density in Bone Marrow Biopsies of Plasma Cell Myeloma Patients br

Ozmen H. I., Seyhanli A., ÖZSAN G. H., ELLİDOKUZ H., ÖZKAL S.

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, vol.33, no.1, pp.29-36, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.4999/uhod.236843
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE
  • Page Numbers: pp.29-36
  • Dokuz Eylül University Affiliated: Yes


Plasma cell myeloma is a monoclonal disease characterized by anemia, monoclonal protein in serum and or urine, osteolytic in bones, hypercalcemia, and renal failure. The study aims to evaluate the percentage of plasma cells in bone marro , the of bone marro involvement, the intensity of fibrosis and angiogenesis in bone marro , and to assess their relationship ith prognostic markers. In this study, bone marro biopsies of 135 plasma cell myeloma cases ere re-evaluated regarding plasma cell percentage and the pattern of bone marro involvement. Fibrosis as assessed in 132 cases ith reticulin staining and vessel density (M D) in 51 cases ith CD34 staining. The relation of these morphological parameters ith stage and survival lesions pattern clinical as analyzed. Plasma cell percentage, involvement pattern and micro-vessel density sho ed statistically significant micro -status correlation ith stage, hile bone marro fibrosis as not significantly correlated (p 0.05, p 0.001, p 0.011, p 0.05, respectively). percentage of plasma cells, diffuse pattern of bone marro involvement, and increase in the degree of fibrosis as correlated increase in M D (p 0.001, p 0.001, p 0.036 respectively). The present study suggested that evaluation of plasma cell infiltration pattern, fibrosis and micro-vessel density in bone marro biopsies of ne ly diagnosed plasma cell myeloma cases be useful tools in the management and maintenance of the treatment. Elevation in ith an percentage, might