Expression of Stromal Caveolin-1 May Be a Predictor for Aggressive Behaviour of Breast Cancer

Eliyatkin N., AKTAŞ S., Diniz G., Ozgur H. H., Ekin Z. Y., Kupelioglu A.

PATHOLOGY & ONCOLOGY RESEARCH, vol.24, no.1, pp.59-65, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1007/s12253-017-0212-8
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.59-65
  • Keywords: Breast cancer, Caveolin 1, Predictive biomarker, FIBROBLASTS, GENE
  • Dokuz Eylül University Affiliated: Yes


Caveolin-1 (Cav-1) is well known as a principal scaffolding protein of caveolae which are specialized plasma membrane structures. The role of Cav-1 in tumorigenesis of breast cancers is relatively less studied. The aim of the present study is to describe the biological roles of Cav-1 in breast cancers considering its contrasting dual functions as an oncogene and as a tumor suppressor. This study included 71 females with breast cancer who had been histopathologically diagnosed in Private Gunes Pathology Laboratory between the years 2007, and 2012. The mean age is 52.48 +/- 12.8 years. Patients were followed up for a mean period of 47.97 +/- 20.48 months. We didn't determine Cav-1 positive tumor cells. In 36 cases (50.7%), there were stromal expressions of Cav-1. In the statistical analysis, there was a statistically significant correlation between Cav-1 expression and ER (p = 0.033), metastasis (p = 0.005), lymphatic invasion (p = 0.000), nodal metastasis (p = 0,003), perinodal invasion (p = 0.003), metastasis (p = 0.005) and survival (p = 0.009). We found that Cav-1 expression is associated with tumor size, histological grade, lymph node involvement. Accordingly, we have suggested that Cav-1 may be a predictive biomarker for breast cancer.