Epigenetic Changes in Autism Spectrum Disorders: An Overview of Short Noncoding RNAs Otizm Spektrum Bozukluklarında Epigenetik Değişiklikler: Kısa Kodlamayan RNA’lara Genel Bakış


Binici N., Şahbudak B.

Turkish Journal of Child and Adolescent Mental Health, cilt.30, sa.2, ss.117-122, 2023 (Scopus, TRDizin) identifier identifier

Özet

Autism spectrum disorder is a neurodevelopmental disorder characterized by delays or deviations in social interaction and communication, lack of interest in the social environment, repetitive-restrictive-anomalous behaviors and interests, and insistence on sameness. In recent years, studies on etiopathogenesis of autism have focused on epigenetic changes. Among epigenetic mechanisms non-coding RNAs (ncRNA) which do not code proteins and lead to transcripts which do not translate into proteins have become the recent focus of research. Interest in short ncRNAs (sncRNA) is increasing especially in the etiology of neurodevelopmental disorders. In this review, our aim was to review the sncRNA, their relationship with autism and values as a target molecule in etiology and treatment.