Correlation of Nm23 and P27 Expression in Nodal Diffuse Large B Cell Lymphomas with Clinicopathologic Parameters and the Effect on Prognosis

Dere Y., Calli A. O., Alacacioglu İ., Kucukzeybek B. B., Bener S., Payzin B.

ERCIYES MEDICAL JOURNAL, cilt.36, sa.2, ss.53-57, 2014 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/etd.2014.7752
  • Dergi Adı: ERCIYES MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.53-57
  • Anahtar Kelimeler: Lymphoma, B-Cell, NM23 nucleoside diphosphate kinases, cyclin-dependent kinase inhibitor p27, prognosis
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Diffuse large B cell lymphoma (DLBCL) is the most common type of adult lymphoma. No certain histopathological parameter was found, except proliferation index, for predicting prognosis. In hematological malignancies, the prognostic effect of Nm23 expression, which shows metastatic potential in solid tumors, has been researched by a few studies. Loss of p27, a negative regulator of the cell cycle, indicates aggressiveness; however, some studies showed that high expression is relevant to poor prognosis. Here, we aimed to investigate whether they can be used as prognostic markers in DLBCLs.