Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats

Kizmazoglu C., Aydin H. E., Sevin I. E., KALEMCİ O., YÜCEER N., Atasoy M. A.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, vol.58, no.6, pp.508-512, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.3340/jkns.2015.58.6.508
  • Journal Name: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.508-512
  • Keywords: Resveratrol, Brain Ischemia, Annexin V, Bcl-2, p53
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V.