Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, cilt.58, sa.6, ss.508-512, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 58 Sayı: 6
- Basım Tarihi: 2015
- Doi Numarası: 10.3340/jkns.2015.58.6.508
- Dergi Adı: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.508-512
- Anahtar Kelimeler: Resveratrol, Brain Ischemia, Annexin V, Bcl-2, p53
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V.