Disposition kinetics and effects of menthol

Gelal A., Jacob P., Yu L., Benowitz N.

CLINICAL PHARMACOLOGY & THERAPEUTICS, vol.66, no.2, pp.128-135, 1999 (SCI-Expanded) identifier identifier


Background: Menthol is widely used in a variety of commercial products and foods, but its clinical pharmacology is not well studied. To determine the disposition kinetics and to examine subjective and cardiovascular effects of menthol, we conducted a crossover placebo-controlled study that compared pure menthol versus placebo, along with an uncontrolled exposure to menthol in food or beverage. A novel assay for the measurement of menthol in biological fluids was also developed.