Disposition kinetics and effects of menthol


Gelal A., Jacob P., Yu L., Benowitz N.

CLINICAL PHARMACOLOGY & THERAPEUTICS, cilt.66, sa.2, ss.128-135, 1999 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 2
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1053/cp.1999.v66.100455001
  • Dergi Adı: CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.128-135
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Menthol is widely used in a variety of commercial products and foods, but its clinical pharmacology is not well studied. To determine the disposition kinetics and to examine subjective and cardiovascular effects of menthol, we conducted a crossover placebo-controlled study that compared pure menthol versus placebo, along with an uncontrolled exposure to menthol in food or beverage. A novel assay for the measurement of menthol in biological fluids was also developed.