Disposition kinetics and effects of menthol

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Gelal A., Jacob P., Yu L., Benowitz N.

CLINICAL PHARMACOLOGY & THERAPEUTICS, vol.66, no.2, pp.128-135, 1999 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 66 Issue: 2
• Publication Date: 1999
• Doi Number: 10.1053/cp.1999.v66.100455001
• Journal Name: CLINICAL PHARMACOLOGY & THERAPEUTICS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.128-135
• Dokuz Eylül University Affiliated: Yes

Abstract

Background: Menthol is widely used in a variety of commercial products and foods, but its clinical pharmacology is not well studied. To determine the disposition kinetics and to examine subjective and cardiovascular effects of menthol, we conducted a crossover placebo-controlled study that compared pure menthol versus placebo, along with an uncontrolled exposure to menthol in food or beverage. A novel assay for the measurement of menthol in biological fluids was also developed.