Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens

Senni, Michele; McMurray, John; Wachter, Rolf; McIntyre, Hugh; Reyes, Antonio; Majercak, Ivan; Andreka, Peter; Shehova-Yankova, Nina; Anand, Inder; YILMAZ, MEHMET; Gogia, Harinder; Martinez-Selles, Manuel; Fischer, Steffen; Zilahi, Zsolt; Cosmi, Franco; Gelev, Valeri; Galve, Enrique; Gomez-Doblas, Juanjo; Nociar, Jan; Radomska, Maria; Sokolova, Beata; Volterrani, Maurizio; Sarkar, Arnab; Reimund, Bernard; Chen, Fabian; Charney, Alan

doi:10.1002/ejhf.548

Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens

Senni M., McMurray J. J. V., Wachter R., McIntyre H. F., Reyes A., Majercak I., ...More

EUROPEAN JOURNAL OF HEART FAILURE, vol.18, no.9, pp.1193-1202, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 18 Issue: 9
Publication Date: 2016
Doi Number: 10.1002/ejhf.548
Journal Name: EUROPEAN JOURNAL OF HEART FAILURE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1193-1202
Keywords: LCZ696, Sacubitril, Valsartan, ARNI, Heart failure, Tolerability
Open Archive Collection: AVESIS Open Access Collection
Dokuz Eylül University Affiliated: No

Abstract

AimsTo assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction 35%).