Effect of Fetal Sex on Apoptosis-Regulating Proteins in Trophoblasts of Full-Term Human Placenta
GYNECOLOGIC AND OBSTETRIC INVESTIGATION, cilt.67, sa.1, ss.53-56, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 67 Sayı: 1
- Basım Tarihi: 2008
- Doi Numarası: 10.1159/000161570
- Dergi Adı: GYNECOLOGIC AND OBSTETRIC INVESTIGATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.53-56
- Anahtar Kelimeler: Fetal gender, hCG, Bcl-2, Bax
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Objective: Pregnant women with female fetuses have higher maternal serum human chorionic gonadotropin (hCG) levels compared to those pregnant women with male fetuses. Apoptosis in the placenta has a role in hCG secretion. In the present study, we examined the effect of fetal gender on apoptosis-regulating proteins in the trophoblast cells of human term placenta. Study Design: 34 uncomplicated, singleton, term pregnancies, 17 had male and 17 had female fetuses, were recruited in the study. Apoptosis-regulating proteins of the trophoblast cells were measured by using immunohistochemistry for Bcl-2 and Bax. Staining index values were compared between the female and male pregnancies. Results: There were no sex differences in Bcl-2 and Bax proteins. There were no correlations between maternal serum and cord blood hCG levels, and staining index values of two proteins in trophoblast cells. Conclusions: The difference in maternal serum and cord blood hCG levels in correlation with fetal sex is not associated with apoptosis-regulating proteins in the trophoblast cells of human term placenta. Copyright (C) 2008 S. Karger AG, Basel