Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

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Koçdor H., Ateş H., Aydın S., Cehreli R., Soyarat F., Kemanli P., ...Daha Fazla

DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.9, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2147/dddt.s87662
  • Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: lung cancer, zinc, docetaxel, A549, H1299, PROSTATE-CANCER, OXIDATIVE STRESS, EXOGENOUS ZINC, DNA-DAMAGE, P53, EXPRESSION, TAXANES, CYCLE, DEFICIENCY, RESISTANCE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Exposure to exogenous zinc results in increased apoptosis, growth inhibition, and altered oxidative stress in cancer cells. Previous studies also suggested that zinc sensitizes some cancer cells to cytotoxic agents depending on the p53 status. Therefore, zinc supplementation may show anticancer efficacy solely and may increase docetaxel-induced cytotoxicity in non-small-cell lung cancer cells.