Limitations of Cross-Talk Between Osteosarcoma and Bone Marrow-Derived Mesenchymal Stem Cells

Başbınar Y., Uysal T., Karaca C., Daskin E., Meco H. E., Pakdemirli A., ...More

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.3, no.2, pp.83-88, 2019 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.30621/jbachs.2019.611
  • Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.83-88
  • Keywords: Osteosarcoma, MG-63, BM-MSCs, Metastasis, Cross-Talk, BREAST-CANCER CELLS, N-CADHERIN, METASTASIS, GROWTH, BIOGENESIS, EXOSOMES
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: Metastasis is a multi-step process which leads the tumor cells to escape from primer tumor region due to their need to gain malign phenotypes. While the effect of bone marrow-derived mesenchymal stem cells upon metastasis is not certain, some studies point out bone marrow-derived mesenchymal stem cells (BM-MSCs) to have this ability due to cell-cell interaction, released cytokines, and organization with the extracellular matrix in the micro-environment. Cross-talk via soluble factors also shifts the metastatic character.