H-1 spin-lattice relaxation in water solution of Bi-209 counterparts of Gd(3+)contrast agents

Creative Commons License

Kruk D., Umut E., Masiewicz E., Hermann P., Scharfetter H.

MOLECULAR PHYSICS, cilt.117, sa.7-8, ss.927-934, 2019 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117 Sayı: 7-8
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/00268976.2018.1517907
  • Dergi Adı: MOLECULAR PHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.927-934
  • Anahtar Kelimeler: NMR, relaxation, dynamics, contrast agents, SLOW-MOTION THEORY, PARAMAGNETIC-COMPLEXES, MAGNETIC-RESONANCE, NUCLEAR-RELAXATION, FIELD, NMR, CONTRAST, ENHANCEMENT, DISPERSION, DYNAMICS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

H-1 spin-lattice relaxation studies of water solutions of Bismuth-ethylenediamine-tetraacetic acid (Bi-EDTA), Bismuth-ethylenediamine-tetrakis(methylenephosphonic) acid (Bi-EDTP), Bismuth-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Bi-DOTA), Bismuth-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid) (Bi-DOTP) and Bismuth-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (Bi-DO3A) have been performed in order to compare Quadrupole Relaxation Enhancement (QRE) effects with Paramagnetic Relaxation Enhancement (PRE) from the perspective of exploiting the first one as a novel contrast mechanism for Magnetic Resonance Imaging (MRI). The selected compounds can be considered as Bi-209 counterparts of Gd3+ complexes. The relaxation experiments have been performed in a broad frequency range of 5kHz-30MHz. The relaxation contribution associated with QRE has been extracted from the data and compared with PRE. Similarities and differences between the two effects have been discussed.