Gray matter abnormalities in Major Depressive Disorder: A meta-analysis of voxel based morphometry studies
JOURNAL OF AFFECTIVE DISORDERS, vol.138, no.1-2, pp.9-18, 2012 (SCI-Expanded, SSCI, Scopus)
- Publication Type: Article / Review
- Volume: 138 Issue: 1-2
- Publication Date: 2012
- Doi Number: 10.1016/j.jad.2011.03.049
- Journal Name: JOURNAL OF AFFECTIVE DISORDERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
- Page Numbers: pp.9-18
- Keywords: Major Depressive Disorder, MRI, Voxel-based-morphometry, Gray matter
- Dokuz Eylül University Affiliated: Yes
Abstract
Background: Voxel-based morphometry (VBM) has been widely used to quantify structural brain changes associated with Major Depressive Disorder (MDD). While some consistent findings have been reported, individual studies have also varied with respect to the key brain regions affected by the illness, and how these abnormalities are related to patients' clinical characteristics. Here, we aimed to identify those brain regions that most consistently showed gray matter anomalies in MDD, and their clinical correlates, using meta-analytic techniques.