Gray matter abnormalities in Major Depressive Disorder: A meta-analysis of voxel based morphometry studies

BORA İ. E., Fornito A., Pantelis C., Yuecel M.

JOURNAL OF AFFECTIVE DISORDERS, vol.138, no.1-2, pp.9-18, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 138 Issue: 1-2
  • Publication Date: 2012
  • Doi Number: 10.1016/j.jad.2011.03.049
  • Journal Name: JOURNAL OF AFFECTIVE DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.9-18
  • Keywords: Major Depressive Disorder, MRI, Voxel-based-morphometry, Gray matter, NATIONAL COMORBIDITY SURVEY, HIPPOCAMPAL VOLUME, ANTERIOR CINGULATE, BRAIN VOLUME, UNIPOLAR DEPRESSION, PANIC DISORDER, HIGH-RISK, MOOD, AMYGDALA, ANXIETY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Voxel-based morphometry (VBM) has been widely used to quantify structural brain changes associated with Major Depressive Disorder (MDD). While some consistent findings have been reported, individual studies have also varied with respect to the key brain regions affected by the illness, and how these abnormalities are related to patients' clinical characteristics. Here, we aimed to identify those brain regions that most consistently showed gray matter anomalies in MDD, and their clinical correlates, using meta-analytic techniques.