İNSAN KANINDAN HEMOGLOBİN UZAKLAŞTIRILMASI İÇİN HEMOGLOBİN BASKILANMIŞ P(HEMA-MAH) KRİYOJELLERİN HAZIRLANMASI

Tez Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: Hacettepe Üniversitesi, Fen Bilimleri Enstitüsü, Kimya A.B.D., Türkiye

Tez Danışmanı: Adil Denizli

Tezin Onay Tarihi: 2009

Tezin Dili: İngilizce

Özet:

Interaction of blood with different organs and tissues culminates in input of new proteins, separation of some others and modification of existent ones. These proteins may experience some changes in a specific physiological or pathological situation. Thus, analysis (proteome) of plasma proteins is a significant source for diagnostic markers and determination of treatment targets. However, plasmodic proteome is too complex due to the wide dilution aperture of proteins existed in its structure. All 90% of plasmodic proteins comprise 10 proteins, 10% of them comprises 12 and the rest 1% comprises the other proteins peculiar to diseases. Because the abundant proteins mask the proteins causing diseases, these proteins must be removed from the blood during the analysis process. Repressed molecular polymers are the kind of polymers which are easy to prepare, durable and the ones capable of molecular identification. These can be considered as means of affinity separation. Macro-cellular monolithic hydrogels, in other words cryogels, are modern chromatographic stand-by materials which have wide pour diameters and joint pours, thus showing little pressure decrease.