Tez Türü: Tıpta Yandal Uzmanlık
Tezin Yürütüldüğü Kurum: University of Toronto, Kanada
Tez Danışmanı: Nigil Haroon
Tezin Onay Tarihi: 2018
Tezin Dili: Türkçe
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Özet:
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the spine and sacroiliac
joints (SIJs) with an unknown etiology. The spectrum of axSpA is thought to start from a pre
radiographic stage and may progress to radiographic sacroiliitis over time. Some axSpA patients
may develop structural damage because of new bone formation in the spine which are known as
syndesmophytes. These structures may limit spinal mobility and can contribute to the functional
impairment, which is a well-known complication of axSpA. In this thesis, through three
manuscripts, we studied different aspects of radiographic progression in axSpA. The first study
focused on the characteristics of axSpA patients who had non-diagnostic SIJs at baseline and
progressed to radiographic axSpA. The second study aimed to address progression rates and
factors predictive of spinal progression in ankylosing spondylitis (AS). In the third study we
investigated the effect of spinal structural damage on spinal mobility in AS.