Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder.

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Paketçi C., Ermiş Ç., Şişman A., Hız S., Baykara B., Yiş U.

Turkish journal of medical sciences, cilt.52, sa.4, ss.1041-1049, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.55730/1300-0144.5406
  • Dergi Adı: Turkish journal of medical sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1041-1049
  • Anahtar Kelimeler: Neurofilament light chain, thrombospondin, autism, neurodegeneration, FIBRILLARY ACIDIC PROTEIN, CEREBROSPINAL-FLUID, CHILDREN, SERUM, BIOMARKER, LYMPHOCYTE, INJURY, RATIO, MODEL, RISK
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/aim: Neurofilaments are intermediary filaments associated with neurodegenerative processes. Thrombospondin-1 (TSP-1) is a biological marker playing a role in synaptogenesis. This study aimed to investigate serum neurofilament light chain (NFL), and TSP1 levels of patients with autism spectrum disorder (ASD) compared to typically developing (TD) children.