Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder.


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Paketçi C., Ermiş Ç., Şişman A., Hız S., Baykara B., Yiş U.

Turkish journal of medical sciences, vol.52, no.4, pp.1041-1049, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.55730/1300-0144.5406
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1041-1049
  • Keywords: Neurofilament light chain, thrombospondin, autism, neurodegeneration, FIBRILLARY ACIDIC PROTEIN, CEREBROSPINAL-FLUID, CHILDREN, SERUM, BIOMARKER, LYMPHOCYTE, INJURY, RATIO, MODEL, RISK
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background/aim: Neurofilaments are intermediary filaments associated with neurodegenerative processes. Thrombospondin-1 (TSP-1) is a biological marker playing a role in synaptogenesis. This study aimed to investigate serum neurofilament light chain (NFL), and TSP1 levels of patients with autism spectrum disorder (ASD) compared to typically developing (TD) children.