Akademik Veri Yönetim Sistemi
ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY, cilt.18, sa.1, ss.22-28, 2017 (SCI-Expanded)
Objective: The purpose of this study was to evaluate the impact of parental consanguinity on the clinical features in schizophrenia. Methods: The sample of the study was based on DSM-IV schizophrenia patients admitted to Ataturk State Hospital of Sinop betwe 2009 and 2001. Sociodemographic (age, gender, marital status, completed years of education, employment status) and clinical features (family history of psychiatric disorders, age of onset, number of hospitalization), and parental consanguinity were retrieved retrospectively from case registries. Results: A total of 182 patients (51.1% female and mean age 38.8) were included. Frequency of any parental consanguinity and first degree cousin marriages were 19.9% and 13.2% respectively. Mean age of onset of schizophrenia was significantly lower among patients with parental consanguinity than patients with no parental consanguinity (22.1 and 25.5 respectively; t(180)=2.1; p < 0.05). Parental consanguinity was significantly associated with higher number of hospitalization (adjusted odds ratio [OR]=2.8; 95% confidence interval [C1]=1.1-7.1; p < 0.02). The association between parental consanguinity and number of hospitalization was slightly stronger in patients whose parents were first degree cousins (adjusted OR= 3.0; 95% CI=1.0-8.7; p < 0.04). Conclusion: Frequency of parental consanguinity in schizophrenia is similar to rates in general population, however first degree cousin consanguinity may be mildly higher in parents. Parental consanguinity is associated with earlier age of onset and higher number of hospitalization. Both associations may indicate a relative poor prognosis, and are mildly stronger in first degree cousin consanguinity which may represent a unique genetic effect.