Effect of vascular endothelial growth factor on fetal vessels among obese pregnant women

Janbakhishov T., Caglayan E., Acet F., Altunyurt S., Özer E.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, cilt.151, sa.2, ss.231-236, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 151 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/ijgo.13346
  • Dergi Adı: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Gender Studies Database, MEDLINE, Public Affairs Index
  • Sayfa Sayıları: ss.231-236
  • Anahtar Kelimeler: Fetal vasculature, Obesity, Placental vascularity, Vascular endothelial growth factor, VEGF, MATERNAL OBESITY, INFLAMMATION, PLACENTA, VEGF
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective To determine the role of vascular endothelial growth factor (VEGF) in placental hypoperfusion in obesity. Methods The prospective study enrolled women with a first-trimester singleton pregnancy in Izmir, Turkey, between January and April 2011. Participants were divided into three groups: obese (body mass index [BMI, calculated as weight in kilograms divided by the square of height in meters] >30) with cesarean delivery; normal weight (BMI <30) with vaginal delivery (NVD); and healthy controls (BMI <30) with cesarean delivery. Before delivery, serum C-reactive protein (CRP), and uterine and fetal Doppler measurements were taken. VEGF was evaluated immunohistochemically from the umbilical cord. Results Overall, 109 women completed the study: obesity group (n=13, 11.9%), NVD group (n=50, 45.9%), and control group (n=46, 42.2%). Serum CRP was higher in the obesity group than in the control or NVD groups (P=0.009). VEGF score was highest in the NVD group (9.39 +/- 3.11), and lowest in the obesity group (4.58 +/- 2.78) (P<0.001). VEGF score decreased by 0.81 for each increase in BMI of 1 (P=0.002). Conclusions Maternal obesity was related to decreased VEGF expression. Although not supported by Doppler findings, decreased VEGF expression owing to maternal obesity might trigger endothelial dysfunction and inflammation.