In Silico Analysis of Bioactive Peptides in Invasive Sea Grass Halophila stipulacea

Kandemir Çavaş Ç., Perez-Sanchez H., Mert-Ozupek N., Çavaş L.

CELLS, vol.8, no.6, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.3390/cells8060557
  • Journal Name: CELLS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: bioactive peptides, Halophila stipulacea, in silico analysis, DPP-IV, angiotensin converting enzyme inhibitors, ACE-INHIBITORY PEPTIDE, POTENTIAL PRECURSORS, PROTEIN ISOLATE, MEAT PROTEINS, ANTIOXIDANT, IDENTIFICATION, SEAGRASS, DATABASE, RUBISCO, SEQUENCE
  • Dokuz Eylül University Affiliated: Yes


Halophila stipulacea is a well-known invasive marine sea grass in the Mediterranean Sea. Having been introduced into the Mediterranean Sea via the Suez Channel, it is considered a Lessepsian migrant. Although, unlike other invasive marine seaweeds, it has not demonstrated serious negative impacts on indigenous species, it does have remarkable invasive properties. The present in-silico study reveals the biotechnological features of H. stipulacea by showing bioactive peptides from its rubisc/o protein. These are features such as antioxidant and hypolipideamic activities, dipeptidyl peptidase-IV and angiotensin converting enzyme inhibitions. The reported data open up new applications for such bioactive peptides in the field of pharmacy, medicine and also the food industry.