Akademik Veri Yönetim Sistemi
15th European Paediatric Neurology Society Congress, Praha, Çek Cumhuriyeti, 20 - 24 Haziran 2023, ss.269
Objective: Although many etiological causes (genetic, structural, metabolic) have been identified for epilepsies starting underage
of two years, a clear etiology cannot be determined in significant part of patients. Imaging and genetic-based studies in the early
stages of life have a very important role in the etiology of epilepsy
Methods: Patients diagnosed with epilepsy under age of two between 2011-2016 and 2016-2021 in the Department of Child
Neurology at Dokuz Eylül University were evaluated. Etiologies, seizure types, follow-up, treatment and prognosis of the patients
were determined retrospectively from archive files. Patients with febrile, symptomatic and single afebrile seizures were not
included in the study.
Results: The number of patients in Group1 was 328 and the number of patients in Group2 was 327. When evaluated in terms of
the etiology of epilepsy, structural abnormalities were significantly higher in Group1 (Group1 n=113, Group2 n=98 p<0.05). In
terms of the initial seizure type , the rate of focal seizures was higher in Group1, and generalized seizures were higher in Group2
(Group1: focal seizure n= 109, generalized seizure n=188; Group2: focal seizure n=71, generalized seizure n=256 p<0.05).
Control of seizures with a single antiseizure drug was higher in Group2 (Group2 n=127, Group1 n=117, p<0.05). Neuromotor
developmental retardation at the time of diagnosis (Group1 n=194, Group2 n=161, p<0.05) and mortality rates were significantly
higher in Group1. The most common choice of antiseizure drug was phenobarbital between 2011 and 2016 and levetiracetam
between 2016-2021. In Group 1, 7.3% (n=24) of the patients had a genetic diagnosis before 2016. In Group 2, the percent of
patients with a specific genetic diagnosis was 10.7% (n=35).
Conclusions: The results of our study showed that the etiology, seizure classification and antiseizure drug choice changed over
time. We suggest that this may be due to medical and treatment advances in medicine.
Keywords:
childhood, epilepsy, anti-seizure medication, prognosis