The effect of atorvastatin on lung histopathology in a murine model of chronic asthma


Firinci F., KARAMAN M., CİLAKER MIÇILI S., BAĞRIYANIK H. A., UZUNER N., KARAMAN Ö.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.42, no.4, pp.355-361, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1016/j.aller.2013.09.002
  • Journal Name: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.355-361
  • Keywords: Asthma, Atorvastatin, Mice, PLATELET-ACTIVATING-FACTOR, AIRWAY INFLAMMATION, ALLERGIC-ASTHMA, IN-VITRO, SMOOTH-MUSCLE, STATINS, SIMVASTATIN, BRONCHOCONSTRICTION, PRAVASTATIN, MECHANISM
  • Dokuz Eylül University Affiliated: Yes

Abstract

Introduction: Atorvastatin is a statin group medicine that reduces the level of serum cholesterol; thus it is used to treat hypercholesterolaemia. Independent of the cholesterol-lowering property of statins they also have anti-inflammatory and immunomodulating effects. This study aimed to investigate the effect of atorvastatin on histological changes in the lungs in a murine model of chronic asthma.