An elderly diabetic case of ochronosis with depression and chronic pain


Naharci M. I., Ak M., Bozoglu E., Karadurmus N., IŞIK A. T., Doruk H.

ENDOKRYNOLOGIA POLSKA, cilt.61, sa.6, ss.710-713, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 6
  • Basım Tarihi: 2010
  • Dergi Adı: ENDOKRYNOLOGIA POLSKA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.710-713
  • Anahtar Kelimeler: alkaptonuria, chronic pain, depression, elderly, ochronosis, diabetes mellitus
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Alkaptonuria (ochronosis) is a rare autosomal recessive disorder featuring a genetic error in the amino acid metabolism. A defect in the tyrosine metabolism results in the accumulation and deposition of homogentisic acid in connective tissue, causing a blue-black discolouration. Degenerative arthropathy of the spine, knee, and hip are common signs of ochronosis in older age. An association between ochronosis and depression has not previously been discussed in the literature. This case report describes a 69 year-old woman with diabetes mellitus, ochronosis, depression and chronic pain. (Pol J Endocrinol 2010; 61 (6): 710-713)