In vitro effect of resveratrol against oxidative injury of human coronary artery endothelial cells

SAYIN O., ARSLAN N., ALTUN Z. S., Akdogan G.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.41, no.2, pp.211-218, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.3906/sag-0907-128
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.211-218
  • Keywords: Resveratrol, human coronary artery endothelial cell, oxidative stress, PRIMARY RAT HEPATOCYTES, VASCULAR SMOOTH-MUSCLE, HYDROGEN-PEROXIDE, CELLULAR ANTIOXIDANTS, CLINICAL-IMPLICATIONS, PHASE-2 ENZYMES, PROTECTS, STRESS, DAMAGE, GLUTATHIONE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: Reactive oxygen species induce oxidative stress that may contribute to endothelial dysfunction. In addition to endogen antioxidants, adding antioxidants to diet has been used to reduce oxidative-stress-induced endothelial dysfunction. Resveratrol is a natural phytoalexin which has many effects including antioxidant activity. The aim of this study was to investigate whether resveratrol could protect human coronary artery endothelial cells against in vitro oxidative-stress-mediated injury.