ORGANOID AS A NOVEL TECHNOLOGY FOR DISEASE MODELING

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Sever T., Cevik I., Calibasi-Kocal G., BAŞBINAR Y., ELLİDOKUZ E. B.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.5, sa.1, ss.94-101, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.30621/jbachs.868837
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.94-101
  • Anahtar Kelimeler: Organoid, Disease Modeling, Stem Cell, PLURIPOTENT STEM-CELLS, ZIKA VIRUS-INFECTION, COLORECTAL-CANCER, CEREBRAL ORGANOIDS, BREAST-CANCER, PATIENT, CULTURES, GENERATION, DERIVATION, MUTATIONS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The organoid technology is capable to create more real-like in vitro models in terms of structure and function of the origin of the tissue. Since the three-dimensional model is able to illustrate disease pathology, cell differentiation, and recapitulation of self-renewal, lead organoid technology as a promising disease model to fill the gap between conventional two-dimensional, and in vivo disease models. The review describes the recent development of organoid disease modeling approaches.