Effects of the intrathecally administered ketorolac trometamin on spinal cell injury in trauma model of medulla spinalis in rats Ratlarda oluşturulan medulla spinalis travma modelinde i̇ntratekal yolla verilen ketorolak trometamin'in spinal hücre hasarma etkisi


Alaygut E., KÜÇÜKGÜÇLÜ S., GÖKMEN A. N., BAĞRIYANIK H. A., YILMAZ O., Günerli A.

Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, vol.36, no.3, pp.153-161, 2008 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2008
  • Journal Name: Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.153-161
  • Keywords: Cell demage, Intrathecal, Ketorolac
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: The aim of this study was to investigate the effects of intrathecally administered ketorolac trometamin on spinal cell damage, in spinal cord traumatized rats. Materials and Methods: The spinal cord was traumatized, after spinal catheter was placed and fixed to the each rat under anesthesia. The subjects were randomized into three groups: Group S (n:6); saline solution (10 μL) was administered through catheter Group K5O (n:6); Fifty microgram ketorolac trometamin solution was diluted in 10 μL of saline and was administered through catheter; Group K400 (n:6); Four hundred microgram ketorolac trometamin was diluted in 10 μL of saline and was administered through catheter. The scores according to the "Behavior Rating Scale (BRS)" were determined at the 4th, 12th, 24 th, 48th and 72nd hours after intrathecally administration of ketorolac tromethamin. The cross sections of spinal cord were examined pathologically. The percentage of the damaged spinal cord area was determined in cross sections. Results: When groups were compared according to the BRS scores; the mean values of the BRS scores was significantly high in group K400 (p<0.05) at 48th and 72nd hours. The mean values of the damaged spinal cord area were significantly low in group K50 and group K400 (p<0.05). The mean values of the histopathology scores were compared and it was significantly low in group K400 (p<0.05). Conclusion: In this study, intrathecally administration of 400 μg ketorolac tromethamine resulted in the attenuation of the spinal cell damage in spinal cord traumatized rats.