A comparison of the effects of infliximab, adalimumab, and pentoxifylline on rats with non-alcoholic steatohepatitis

Yalcin M., AKARSU M., ÇELİK A., SAĞOL Ö., TUNALI S., Ertener O., ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.25, ss.167-175, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/tjg.2014.5121
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.167-175
  • Anahtar Kelimeler: Non-alcoholic steatohepatitis, infliximab, adalimumab, pentoxifylline, rats, NON-ALCOHOLIC STEATOHEPATITIS, URSODEOXYCHOLIC ACID, TNF-ALPHA, NECROSIS, FIBROSIS, MODEL, INFLAMMATION, STEATOSIS, DEFICIENT, ANTIBODY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Aims: Non-alcoholic steatohepatitis (NASH) lacks effective medical treatment. Since tumor necrosis factor alpha (TNF-alpha) plays an important role in NASH pathogenesis, we aimed to investigate drugs affecting TNF-a as possible treatment options during the development of NASH.