Modulation of nitric oxide response by fluoroquinolones


Gulay Z., Yucesoy M., Yulug N.

10th Mediterranean Congress of Chemotherapy, Antalya, Türkiye, 20 - 25 Ekim 1996, ss.155-158 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası:
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.155-158
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

In this study, we examined the effects of fluoroqinolones, namely ciprofloxacin (CIP) and ofloxacin (OFX) on nitric oxide (NO) production in an in vitro lipopolysaccharide(LPS)-activated macrophage model. Thioglycollate-elicited;ed peritoneal cells from BALB/c mice were exposed to varying concentrations of CIP and OFX for 1 or 4 days before LPS stimulation. NO response was measured by nitrite accumulation. On the first day of antibiotic exposure, nitrite production after LPS stimulation (1 mu g/ml) decreased by 49.3% (p<0.05), 77.9% (p<0.05), 3.8% (p>0.05) and by 29.7% (p<0.05), 20.5% (p<0.O5), 0.0% (p>0.05) in the presence of 1 mM, 100 mu M and 10 mu M CIP and OFX, respectively. The inhibitory effects did not change significantly after 4 days' of exposure. The results indicate that, in this in vitro murine macrophage model, fluoroquinolones inhibit nitrite production in a dose-dependent manner and may have similar immunomodulatory effects in vivo.