Cyclosporine A toxicity in association with reduced renal mass.

Guray M., SARIOĞLU S., Turkmen M., Yilmaz O., ELLİDOKUZ H., Gelal A., ...Daha Fazla

Transplantation proceedings, cilt.35, sa.8, ss.3128-33, 2003 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 8
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/j.transproceed.2003.10.029
  • Dergi Adı: Transplantation proceedings
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3128-33
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The long-term effect of cyclosporine A (CsA) in male Wistar rats with reduced renal mass was studied. The aim of the study was to highlight the relationship of CsA effect on rats, simulating patients with two functioning kidneys (eg, heart, liver transplant recipients) and one kidney (renal transplant recipients). The Wistar rats were subjected to unilateral nephrectomy (Unx, n = 14) and to 5/6 nephrectomy (STnx, n = 14). Half of these rats and half of the sham operated ones (control, n = 13) were administered CsA (10 mg/kg/d) for 28 days IP. The serum creatinine (S-CR), total protein (S-P), and urine protein (Up) values as well as the whole blood CsA levels were determined on the 28th day of the study. The remnant kidneys were evaluated by image analyses and semiquantitative methods after sacrifice on the 28th day.