Bioadhesive controlled release systems of ornidazole for vaginal delivery

BALOĞLU E., Oezyazici M., Hizarcioglu S. Y., Senygit T., Oezyurt D., Pekcetin Ç.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, cilt.11, sa.4, ss.477-484, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/10837450600939784
  • Dergi Adı: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.477-484
  • Anahtar Kelimeler: ornidazole, vaginal tablet, bioadhesion, swelling-controlled, carbopol 934, CONTROLLED DRUG-DELIVERY, BACTERIAL VAGINOSIS, DOSAGE FORMS, POLYMERS, METRONIDAZOLE, FORMULATION, HYDROGELS, MATRIX
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Our objective was to develop a bioadhesive vaginal tablet formulation of ornidazole by using different polymer mixtures, to evaluate the bioadhesive tablet properties, and to investigate the irritation potential of the formulations to the rat vaginal tissue. Vaginal tablets of ornidazole were directly compressed with bioadhesive and swellable polymer mixtures as release-controlled agents. Carbopol 934 (Cp), pectin (Pc), hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose (Na CMC), and guar gum (GG) were used in different ratios. Bioadhesive properties, swelling capacity, release studies, and histological studies of the formulations were carried out. The bioadhesive strength between bovine vagina and surface of the tablets was determined by tensile experiments, and it was found to be dependent on Cp content. The release mechanism was described and found to be non-Fickian for all formulations. Dissolution data were evaluated statistically. No histological damage was found except one formulation containing high amount of guar gum.