Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease

SAYIN O., Tokgoz Y., ARSLAN N.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.27, pp.479-484, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2014
  • Doi Number: 10.1515/jpem-2013-0296
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.479-484
  • Keywords: adolescent, adropin, fatty liver disease, leptin, obesity, INSULIN-RESISTANCE, HEPATIC STEATOSIS, CHILDHOOD OBESITY, CHILDREN, ADIPONECTIN, ADOLESCENTS, ADIPOKINES, PLASMA, STEATOHEPATITIS, HOMEOSTASIS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: Nonalcoholic fatty liver disease (NAFLD) is the accumulation of excess fat in the liver in the absence of alcohol consumption, which is commonly associated with obesity and increased risk of atherosclerosis as well as insulin resistance. Adropin is a recently identified protein encoded by the gene related with energy homeostasis, which is expressed in the liver and the brain and has a role in preventing insulin resistance and obesity. The aim of this study was to investigate the serum adropin and leptin levels in obese adolescents and compare the patients with, and without, NAFLD and with healthy controls.