Clinical and laboratory evaluation of cases with Periodic Fever Aphtous Stomatitis, Pharyngitis and Adenopathy syndrome

Hizarcioglu M., ASİLSOY S., Oezek G. D., Agin H., Kayserili E., Guelez P., ...Daha Fazla

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.28, sa.5, ss.648-652, 2008 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 5
  • Basım Tarihi: 2008
  • Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.648-652
  • Anahtar Kelimeler: relapsing fever, pharyngitis, stomatitis, aphthous, FAMILIAL MEDITERRANEAN FEVER, PFAPA SYNDROME, APHTHOUS STOMATITIS, ADENITIS, AMYLOIDOSIS, CHILDREN
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Objective: Periodic Fever Aphatous Stomatitis, Pharyngitis and Adenopathy (PEAPA) syndrome is characterized by fever, aphthous stomatitis, tonsillitis, pharyngitis and cervical adenopathy. This syndrome is sporadic and has no specific laboratory findings. The aim of this study was to evaluate the clinical and laboratory findings of the patients with PFAPA syndrome and to determine the response to administered therapies. Material and Methods: Patients who presented with periodic fever and were diagnosed with the PFAPA syndrome between January 2005 and January 2008 were evaluated retrospectively. Results: In this study, we evaluated 12 children (9 males) with PFAPA syndrome, between the ages of 2 to 5 years. Clinical findings started at a mean age of 19.83 +/- 11.51 months. Febrile attacks lasted for 3-6 days and they recurred every 4.16 +/- 1.11 weeks. Other symptoms associated with high fever were pharyngitis (100%), cervical adenopathy (91%), aphtous stomatitis (66%) and exudative tonsillitis (58%). All patients were given oral prednisolone (1-2 mgr/kg/day) and their body temperature temporarily decreased within 2 to 8 hours and did not increase up to the next cycle. The period between febrile episodes seemed to lengthen following steroid therapy; however the symptoms recurred. Three patients were given cimetidine. One of them had a longer period between febrile episodes, however the other two were not affected. Two patients who had undergone adenotonsillectomy did not have any Febrile episodes. Conclusion: PFAPA syndrome can be easily diagnosed by detailed history, physical findings and observation of the patients who have periodic febrile episodes with tonsillopharyngitis. Early diagnosis will also prevent unnecessary antibiotic therapy in such patients.