The effects of intra-cerebroventricular administered rocuronium on the central nervous system of rats and determination of its epileptic seizure-inducing dose


Baykal M., Gokmen N., Dogan A., Erbayraktar S., YILMAZ O., ÖÇMEN E., ...More

REVISTA BRASILEIRA DE ANESTESIOLOGIA, vol.67, no.1, pp.1-5, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1016/j.bjane.2015.02.010
  • Journal Name: REVISTA BRASILEIRA DE ANESTESIOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-5
  • Keywords: Rocuronium, Seizure, Central nervous system, Rat, CEREBROSPINAL-FLUID, INJECTION, LAUDANOSINE, VECURONIUM, ATRACURIUM
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: The aim of this study was to investigate the effects of intracerebroventricularly administered rocuronium bromide on the central nervous system, determine the seizure threshold dose of rocuronium bromide in rats, and investigate the effects of rocuronium on the central nervous system at 1/5, 1/10, and 1/100 dilutions of the determined seizure threshold dose.