Assessment of Rac1 and beta-PAK Expressions in a Mouse Model for Contrast-Induced Nephropathy

MANİSALIGİL Y. A., CİLAKER MIÇILI S., KIZILDAĞ S., BAĞRIYANIK H. A., GÜMÜŞTEKİN M., Celik A.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.4, no.3, pp.230-236, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.30621/jbachs.2020.1057
  • Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.230-236
  • Keywords: apoptosis, contrast-induced nephropathy, iohexol, mouse, Rac1, RADIOCONTRAST-INDUCED NEPHROPATHY, KIDNEY INJURY, ACTIVATION, STRESS, FAMILY, RATS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: Radiocontrast-induced nephropathy is an important clinical problem in high-risk patients. The mechanism of cytotoxic effect of radiocontrast media on kidneys is still not fully clarified. Rac1/beta-PAK pathway has been shown to play a role in other nephropathies such as diabetic nephropathy. In this study, it was aimed to determine whether Rac1/beta-PAK signalling pathway has any role in the development of contrast-induced nephropathy (CIN).