Fish scale/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibrous composite scaffolds for bone regeneration

Kara A., ÇOLPANKAN GÜNEŞ O., ZİYLAN A., Bilici G., ERBİL G., HAVITÇIOĞLU H.

JOURNAL OF BIOMATERIALS APPLICATIONS, cilt.34, sa.9, ss.1201-1215, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 9
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1177/0885328220901987
  • Dergi Adı: JOURNAL OF BIOMATERIALS APPLICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Communication Abstracts, Compendex, EMBASE, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1201-1215
  • Anahtar Kelimeler: Fish scale, scaffold, PHBV, wet-electrospinning, bone regeneration, bone filling material, HYDROXYAPATITE SCAFFOLD, SCALE COLLAGEN, POTENTIAL USE, TISSUE, SKIN, BIOCOMPATIBILITY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study was to produce three-dimensional, nanofibrous fish scale/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composite scaffolds as bone filling materials. This is the first report wherein fish scales were used within a nanofibrous matrix for bone regeneration. Composite scaffolds with a cotton wool-like structure (fiber diameter: 560 +/- 64 nm; porosity: 82%) were obtained by incorporating chopped fish scales into wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibers and freeze-drying. The addition of the fish scales improved the mechanical properties, biomineralization tendency, cell viability, alkaline phosphatase activity, and type I collagen production. Consequently, produced composite scaffolds would be regarded to have the therapeutic capacity in bone tissue damages.