Malnutrition due to bisphosphonate-related osteonecrosis of the jaw in a chronic dialysis patient: case report


Akar G. C., EFEOĞLU C., Alp A., Koseoglu K., Erol H., Yenicerioglu Y., ...More

RENAL FAILURE, vol.35, no.7, pp.1008-1012, 2013 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.3109/0886022x.2013.809005
  • Journal Name: RENAL FAILURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1008-1012
  • Keywords: Malnutrition, osteonecrosis, dialysis patient, bisphosphonate, PROSTATE-CANCER PATIENTS, RISK-FACTORS, AVASCULAR NECROSIS, NUTRITIONAL-STATUS, BONE METASTASES, ORAL-HEALTH, ZOLEDRONATE, DISEASE, PREVALENCE, ABILITY
  • Dokuz Eylül University Affiliated: No

Abstract

Adequate nutrition is imperative for a successful outcome in dialysis patients. Excellent oral hygiene and an efficient mastication can help to correct several metabolic and endocrine disturbances as well as delay initiation of dialysis in patients with chronic renal failure. However, concerns exist about the risk of malnutrition and protein depletion. On the other hand, intravenous bisphosphonates are the current standard of care for the treatment of hypercalcemia of malignancy and for the prevention of skeletal complications associated with bone metastases. Recently, retrospective case studies have reported an association between long-term bisphosphonate therapy and osteonecrosis of the jaws. This complication occurs either spontaneously or after minor dento-alveolar surgery including extraction of teeth. A malnourished dialysis patient who showed the typical clinical features of bisphosphonate-related osteonecrosis of the jaw (BRONJ) without any obvious radiological changes in his panoramic radiograph is reported. To minimize the risk of BRONJ, patients initiated on bisphosphonates should optimize routine dental care and have their baseline oral health evaluated by both clinical and radiographic examinations before initiation of bisphosphonate therapy.