LLM Dergi, vol.3, no.1, pp.14-17, 2019 (Peer-Reviewed Journal)
Acute Aspergillus Laryngotracheobronchitis in a Child with Acute Lymphoblastic Leukemia
ABSTRACT
Invasive fungal infection of the laryngotracheobronchial structures is rarely reported. The
mortality rate in this condition is extremely high, especially for neutropenic patients. Timely
initiation of the adequate antifungal drugs and supportive care is very important to improve the
prognosis. We present a six-year-old girl with acute lymphoblastic leukemia, who was shown to
have invasive pulmonary aspergillosis with laryngotracheobronchitis, which led to respiratory
failure. At the time of intubation, pseudomembranes were seen on the laryngeal structures
and fungal laryngotracheobronchitis was considered. Epiglottis swab culture was positive for
Aspergillus fumigatus and Aspergillus terreus, and the patient was successfully treated with the
combination therapy of voriconazole and caspofungin.
Keywords: Laryngotracheobronchitis; Aspergillus; Leukemia