A Review on The Development, Production Strategies, and Utilization of Monoclonal Antibodies

Sanlay G., Bekcioglu O., Başbınar Y.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.4, sa.3, ss.197-204, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 4 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.30621/jbachs.2020.1243
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.197-204
  • Anahtar Kelimeler: monoclonal antibodies, industry, cancer, PHAGE-DISPLAY, HUMANIZATION METHODS, GENERATION, MICE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Over the last 20 years, monoclonal antibodies have become the backbone of biological therapeutics for the treatment and diagnosis of several diseases. The rising incidence of cancer and other immunologic diseases promoted the increasing investments of the global pharmaceutical industry in monoclonal antibody development. The R&D has focused on the highest efficacy which is majorly correlated with the antigen-binding specificity and the lowest immunogenicity of monoclonal antibodies. This review aims to provide a brief description and explanation of each stage in the development path of mAbs.