Effects of APOE, ACE, PICALM, and CYP2D6 Gene Variants on Alzheimer's Disease


Oz O., YENER G., BORA E., ÇANKAYA T., ATAMAN E., Ercal D., ...More

CURRENT PSYCHIATRY RESEARCH AND REVIEWS, vol.17, no.2, pp.127-136, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.2174/2666082217666210907104004
  • Journal Name: CURRENT PSYCHIATRY RESEARCH AND REVIEWS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, Psycinfo
  • Page Numbers: pp.127-136
  • Keywords: Early-onset Alzheimer's disease, late-onset Alzheimer's disease, APOE, PICALM, ACE, CYP2D6, polymorphism, GENOME-WIDE ASSOCIATION, IDENTIFIES VARIANTS, DEMENTIA, RECOMMENDATIONS, POLYMORPHISM, PREVALENCE, DIAGNOSIS, DONEPEZIL, CLU
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Alzheimer's disease is a multifactorial, neurodegenerative disease which is considered the most common cause of dementia. It is divided into two subtypes based on the age of onset: Early- Onset Alzheimer's Disease (EOAD) and Late-Onset Alzheimer's Disease ( LOAD).