Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study

AKAY, AYNUR; ERESEN YAZICIOĞLU, ÇİĞDEM; ALŞEN GÜNEY, SEVAY; Erkuran, Handan; KIZILDAĞ, SEFA; BAYKARA, HÜSEYİN; Ozyurt, Gonca; Kadicesme, Sebnem; Miral, Suha; Emiroglu, Neslihan

doi:10.1080/24750573.2017.1418134

Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study

Atıf İçin Kopyala

AKAY A., ERESEN YAZICIOĞLU Ç., ALŞEN GÜNEY S., Erkuran H. O., KIZILDAĞ S., BAYKARA H. B., ...Daha Fazla

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, cilt.28, sa.2, ss.177-184, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 28 Sayı: 2
Basım Tarihi: 2018
Doi Numarası: 10.1080/24750573.2017.1418134
Dergi Adı: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.177-184
Anahtar Kelimeler: Attention deficit/hyperactivity disorder, adolescents, catechol-O-methyltransferase gene (COMT), dopamine D4 receptor gene (DRD4), methylphenidate, clinical global impression (CGI), DEFICIT HYPERACTIVITY DISORDER, III REPEAT POLYMORPHISM, HAPLOTYPE RELATIVE RISK, TRANSPORTER GENE, SUSTAINED ATTENTION, NO ASSOCIATION, ADHD, CHILDREN, SCHIZOPHRENIA, GENOTYPE
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

OBJECTIVES: In this study, it was aimed to analyse the relationship between clinical improvement in adolescents with attention deficit/hyperactivity disorder (ADHD) and the presence of allele frequencies of dopamine D4 receptor (DRD4), and Val158Met polymorphism of catechol-O-methyltransferase (COMT) genes.