Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study


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AKAY A., ERESEN YAZICIOĞLU Ç., ALŞEN GÜNEY S., Erkuran H. O., KIZILDAĞ S., BAYKARA H. B., ...Daha Fazla

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, cilt.28, sa.2, ss.177-184, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/24750573.2017.1418134
  • Dergi Adı: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.177-184
  • Anahtar Kelimeler: Attention deficit/hyperactivity disorder, adolescents, catechol-O-methyltransferase gene (COMT), dopamine D4 receptor gene (DRD4), methylphenidate, clinical global impression (CGI), DEFICIT HYPERACTIVITY DISORDER, III REPEAT POLYMORPHISM, HAPLOTYPE RELATIVE RISK, TRANSPORTER GENE, SUSTAINED ATTENTION, NO ASSOCIATION, ADHD, CHILDREN, SCHIZOPHRENIA, GENOTYPE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

OBJECTIVES: In this study, it was aimed to analyse the relationship between clinical improvement in adolescents with attention deficit/hyperactivity disorder (ADHD) and the presence of allele frequencies of dopamine D4 receptor (DRD4), and Val158Met polymorphism of catechol-O-methyltransferase (COMT) genes.