Histopathologic changes of the lung in newborn mice born from asthmatic mothers


Babayigit A., Oelmez D., Erbil G., Karaman O., BAĞRIYANIK H. A., YILMAZ O., ...More

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.28, no.5, pp.606-611, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 5
  • Publication Date: 2008
  • Journal Name: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.606-611
  • Keywords: asthma, animals, newborn, pathology, lung, CHILDHOOD ASTHMA, IMMUNE-SYSTEM, MURINE MODEL, EARLY-LIFE, ALLERGEN, PREGNANCY, EXPOSURE, RISK, MILK
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Asthma has its origins in early-life. Maternal asthma is an important risk factor, the mechanism of this effect is still unknown. The aim of this study was to evaluate the histopathologic changes of the lung in newborn mice born from asthmatic mother. Material and Methods: 28 BALB/c mice were divided into 4 groups; Group I (Astmatic mother mice), Group II (Control mother mice), Group III (Babies from asthmatic mother) and Group TV (Babies from control group). Mice in group I were sensitized with ovalbumin and mice in group II received saline. Mothers and I-day-old baby mice were sacrified and airway histopathology was evaluated by using light and electron microscopy in all groups. Results: In asthmatic mother mice group (Group I), all histopathologic parameters including thickness of the epithelium, basement membrane and subepithelial smooth muscle were significantly higher when compared with the control group (Group II) (p = 0.000, p = 0.000, p = 0.000 respectively). When Group III and IV were compared with each other, the thickness of the epithelium, basement membrane and subepithelial smooth muscle were significantly higher in babies born from asthmatic mothers (p = 0.000, p = 0.000, p = 0.000 respectively). Conclusion: The results of this study suggest that structural changes of the lung may begin in the prenatal period in babies born from asthmatic mothers. Further studies are needed to clarify the histopathologic changes of the lung in childen of asthmatic mothers, which factors influence these changes and whether these changes are permanent or temporary.